Striker Issa Alekasir's header in the 88th minute found the back of net and sent the Reds to the competition's next round.
According to the simplified measures agreed on by the IOC and Tokyo 2020 last weekend, some details of the torch relay will be simplified, including slimming down the size of the vehicle convoys and simplifying the grand start and celebration events.
Olimpia must defeat Delfin at home and rely on other results going their way to have any chance of progressing to the knockout phase.
In the 33rd minute Fati's acceleration then drew a foul in the area from Mario Gaspar and Messi slotted home the penalty to make it 3-0 and Pau Torres scored an own goal with the last action of the first half when he put Messi's clipped ball past the stranded Asenjo under timid pressure from Busquets.
With the international break around the corner, that means the next time Hazard has a chance of playing would be in Madrid's home game at home to Cadiz on October 18th.
"We expect a very tough match because Pakhtakor are physically strong but we are ready," said Golmohammadi.
AC Milan continued their good form as they won 2-0 away to Crotone, Franck Kessie's penalty put the Rossoneri in charge in the first half, while new arrival Brahim Diaz sealed matters after the break.
Vasco are now fifth in the standings with 18 points while Brangatino are 17th, seven points further back.
Olympic medalist Wang Shun reached the finishing line first in the men's 400m individual medley in 4:11.89.
At the same time, after entering the relegation group, Guangzhou R&F will try to secure its next season's CSL ticket in the second session games.
Roma, Paris Saint-Germain, Ajax, Bayern Munich and Wolverhampton Wanderers have also been linked with the attacker.